DNA damage due to phototherapy: Single or double lights?

The ability of sperm selection techniques to remove single- or double-strand DNA damage.

A wide variety of techniques for the preparation of sperm are currently available, of which the most commonly employed are density-gradient centrifugation (DGC) and swim-up (SUP). To date, these methods appear to be effective in selecting functional sperm for assisted reproduction techniques (ART), but they may have negative effects on sperm DNA. In this study, the ability of these semen proces...

Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response.

The DNA damage signaling pathways mediated by the ataxia-telangiectasia mutated (ATM) and the ATM and Rad3-related (ATR) kinases play crucial roles in the maintenance of genomic integrity and may function as an anti-cancer barrier during early tumorigenesis. Although the ATM and ATR pathways share some of their downstream functions, the DNA damage that evoke these two pathways are distinct. Whi...

Skin Damage Due to Acrylic or Epoxy Adhesives

Extreme bendability of DNA double helix due to bending asymmetry.

Experimental data of the DNA cyclization (J-factor) at short length scales exceed the theoretical expectation based on the wormlike chain (WLC) model by several orders of magnitude. Here, we propose that asymmetric bending rigidity of the double helix in the groove direction can be responsible for extreme bendability of DNA at short length scales and it also facilitates DNA loop formation at th...

Survey of Cardiovascular Damage due to Atherosclerosis in 112 Patients

ABSTRACT Atherosclerosis is one of the most common disorders in Iran. It usually involved adult males over the age of 60 year. All Major and middle arteries are at risk and usually it has two types effects on arteries, Occlusive lesions in the site of dividing arteries and aneurysmal lesions which occure in abdominal aorta in 90%. Frequency, symptoms and pathologies of atherosclosis is still...